Stage 1 of 4
Get your weight under control. Don't harm your body.
Test before. Take the peptide. Test after. Close the loop.
Close the loop on Stage 1
Every element follows the same pattern. Test, act, test.
Metabolic Baseline (11 markers)
Test
HbA1c, fasting glucose, fasting insulin, lipid panel, ALT/AST, BUN/creatinine, TSH, hs-CRP, B12, Vitamin D, Lipase
Order at Ulta↻ Compare results. Adjust. Repeat.
5-Gene Methylation Panel (one-time)
Test
Cheek swab: MTHFR, MTRR, MTR, AHCY, COMT
Coming soonAction
Supplement based on your results — the right form of B12, folate, and methyl donors.
Test
Recheck homocysteine to confirm the supplements are landing.
↻ Compare results. Adjust. Repeat.
Emotional Work (Noom-validated, Joe Hudson method)
Test
Self-assess: where is food anxiety, body image, or self-sabotage right now?
Action
Practice Joe Hudson's VIEW method. Noom's RCTs prove psychological work drives weight loss (78% success rate).
Start with Joe HudsonTest
Reassess after 4-8 weeks. What shifted? What's still stuck?
↻ Compare results. Adjust. Repeat.
AI Lab Analysis
Test
Paste your BEFORE labs into Claude or Grok
Test
Paste your AFTER labs. AI shows you what moved.
↻ Compare results. Adjust. Repeat.
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The 5 genes in your methylation panel
One cheek swab. Five genes. A report you keep for the rest of your life.
MTHFR
Methylenetetrahydrofolate reductase
What it does: Converts folic acid into active methylfolate — the folate your body can actually use.
Why it matters: A variant here means you probably should skip folic acid and take methylfolate directly.
MTRR
Methionine synthase reductase
What it does: Recycles vitamin B12 so methionine synthase keeps working.
Why it matters: A slow MTRR often pairs with B12 symptoms even when B12 looks "normal" on labs.
MTR
Methionine synthase
What it does: Uses B12 to convert homocysteine back into methionine (the main methyl donor).
Why it matters: If this is slow, homocysteine climbs — a marker you will retest every stage.
AHCY
Adenosylhomocysteine hydrolase
What it does: Clears SAH, the byproduct of every methylation reaction, so the cycle can keep turning.
Why it matters: A bottleneck here tells you to watch methionine and SAMe status carefully.
COMT
Catechol-O-methyltransferase
What it does: Breaks down dopamine, norepinephrine, and estrogen metabolites.
Why it matters: Slow COMT variants often feel jittery on caffeine or methylated B-vitamins — dosing matters.
Expected price range: $300-$600 for a one-time test.
Start the loop
Order the baseline panel. Start your GLP-1. Retest at week 8.
Order baseline panel at UltaHow we make money: LoopPep is free. When you use the affiliate links on this page to order tests or sign up for services, we may earn a small commission at no extra cost to you. We are not a medical provider. We do not prescribe or dispense medications. Full disclosure.